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By putting your Exchange server(s) into maintenance mode you are allowing the servers to stop processing all incoming mail and drain anything that is still in the pipeline.
Why would you do this? For 2 reasons. Updates (both Windows and CU's) and to redirect all traffic to other Exchange servers in your enviroment.

I personally run maintanance mode because I have 2 Exchange servers in DAG and want to redirect them. Best practice recommendations is to run this as well even with a single Exchange server to prevent any kind of dataloss.

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